According to research published in 《Supportive Care in Cancer》 in 2020, oral-related symptoms are widespread across all cancer types. The study found that 62% of patients experience taste changes, while 56% suffer from dry mouth. Other prevalent issues include voice changes at 37%, smell changes at 35%, and increased mucus secretion at 33%. Furthermore, 25% of patients encounter difficulties with their teeth or dentures, 20% experience oral or throat pain, and 19% deal with limited mouth opening. These symptoms rarely occur in isolation; instead, they often emerge together, collectively impacting a patient's ability to eat, speak, socialize, and maintain overall comfort.

Among all cancer patients, those receiving radiation therapy for head and neck cancers experience particularly severe oral and mucosal symptoms. A 2015 report in 《Minerva Stomatologica》indicated that during the acute phase, approximately 90% of these patients experience oral mucositis, dry mouth, pain, and taste dysfunction, while roughly 70% suffer from difficulty swallowing. Many of these symptoms may persist long after the treatment has concluded, making them a critical focus for long-term survivorship care.

In light of these challenges, oral moisturizing is considered a fundamental pillar of supportive cancer care. When saliva production decreases and the mucosal barrier become fragile, maintaining oral moisture helps alleviate discomfort and supports the maintenance of daily oral hygiene. Specialized oral care aids, such as Hi-MUPRO Oral Moisturizing Gel and Biotene Oral Balance Gel, are designed to form a protective moisturizing layer on oral surfaces. These products assist the mucosa in remaining hydrated, thereby supporting a stable and comfortable oral environment. Their flavorless, sugar-free, and alcohol-free formulations minimize the risk of irritation, making them ideal auxiliary care options for daily use when managing oral dryness or discomfort.